cosmetic titanium dioxide

Furthermore, titanium dioxide rutile manufacturers continuously innovate and develop new products to meet evolving market demands. This includes the development of specialized grades of titanium dioxide rutile with enhanced properties, such as higher opacity, increased durability, or improved weather resistance. By offering a diverse range of products, manufacturers can cater to a wide range of applications and industries, further expanding their market reach.

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In an early study Jani et al. administred rutile TiO2 (500 nm) as a 0.1 ml of 2.5 % w/v suspension (12.5 mg/kg BW) to female Sprague Dawley rats, by oral gavage daily for 10 days and detected presence of particles in all the major gut associated lymphoid tissue as well as in distant organs such as the liver, spleen, lung and peritoneal tissue, but not in heart and kidney. The distribution and toxicity of nano- (25 nm, 80 nm) and submicron-sized (155 nm) TiO2 particles were evaluated in mice administered a large, single, oral dosing (5 g/kg BW) by gavage. In the animals that were sacrificed two weeks later, ICP-MS analysis showed that the particles were retained mainly in liver, spleen, kidney, and lung tissues, indicating that they can be transported to other tissues and organs after uptake by the gastrointestinal tract. Interestingly, although an extremely high dose was administrated, no acute toxicity was observed. In groups exposed to 80 nm and 155 nm particles, histopathological changes were observed in the liver, kidney and in the brain. The biochemical serum parameters also indicated liver, kidney and cardiovascular damage and were higher in mice treated with nano-sized (25 or 80 nm) TiO2 compared to submicron-sized (155 nm) TiO2. However, the main weaknesses of this study are the use of extremely high single dose and insufficient characterisation of the particles.

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  • Rutile TiO2's significance extends beyond its aesthetic benefits. In the pigment industry, it is the most widely used white pigment due to its superior whiteness and brightness. It imparts excellent covering power and gloss to paint, plastics, and paper, enhancing their overall quality. Moreover, its UV absorbing capabilities make it an essential component in sunscreen formulations, protecting the skin from harmful ultraviolet radiation.